Karvela 800mg 4pcs Tablet

✔️ Uses of Karvela 800

Treats Hyperphosphatemia (high phosphorus level in blood)

✔️ Side Effects of Karvela 800

Abdominal pain, Diarrhea, Flatulence, Vomiting, Constipation, Nausea, Dyspepsia

✔️ How does Karvela 800 work?

Karvela 800 is a chelating agent that helps reduce the phosphorus levels in the blood by binding to the phosphate that enters the body with food and managing its absorption.

✔️ Quick Suggestions:

• Sevelamer is used to control blood phosphate levels in patients who are on dialysis treatment.
• You must take it with food and stick to the diet prescribed by your doctor.
• You may develop low levels of calcium, folic acid, and vitamins A, D, E, and K in your blood. Your doctor may prescribe supplements, if necessary.
• Avoid taking any other medicine 1 hour before or 3 hours after taking Sevelamer.
• Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.

✔️ Indication of Karvela 800

• Control of hyperphosphatemia in adults receiving hemodialysis or peritoneal dialysis.
• Control of hyperphosphatemia in adults with chronic kidney disease (CKD) not on dialysis, with serum phosphorus ≥1.78 mmol/L.
• Should be part of a comprehensive treatment approach, potentially including calcium supplements and vitamin D3 or analogs to manage the renal bone disease.

✔️ Pharmacology

Sevelamer carbonate is a non-absorbed phosphate-binding polymer free of metals and calcium. It binds phosphate in the gastrointestinal tract through ionic and hydrogen bonding, reducing phosphate absorption and lowering serum phosphorus levels.

✔️ Dosage & Administration of Karvela 800

For End-Stage Renal Disease (ESRD) Hemodialysis and Hyperphosphatemia:

Initial Dose:

• Serum PO4 >9 mg/dL [2.91 mmol/L]: 1600 mg orally every 8 hours with meals.
• Serum PO4 7.5-9 mg/dL [2.42-2.91 mmol/L]: 1200-1600 mg orally every 8 hours with meals.
• Serum PO4 5.5-7.5 mg/dL [1.78-2.42 mmol/L]: 800 mg orally every 8 hours with meals.

Maintenance Dose:

• Serum PO4 >5.5 mg/dL [>1.78 mmol/L]: Increase dose by 400-800 mg per meal.
• Serum PO4 3.5-5.5 mg/dL [1.13-1.78 mmol/L]: Maintain current dose.
• Serum PO4 <3.5 mg/dL [1.13 mmol/L]: Decrease dose by 400-800 mg per meal.

Dosing Considerations:

• Titrate the dose by increasing it by 400-800 mg per meal at 2-week intervals.
• Do not exceed a total daily dose of 4 grams.

Switching from Calcium Acetate:

• Substitute 800 mg of SEVELAMER for 667 mg of calcium acetate.
• Substitute 1600 mg of SEVELAMER for 1334 mg of calcium acetate.
• Substitute 2400 mg of SEVELAMER for 2001 mg of calcium acetate.

Pediatric Dose:

• The safety and efficacy of Karvela 800 in children have not been established. It is not recommended for use in pediatric patients.

✔️ Interaction

Drug-Drug Interactions:

• Ciprofloxacin: Karvela 800 may decrease the absorption of ciprofloxacin. It should not be taken simultaneously with this antibiotic.
• Mycophenolate: Karvela 800 may affect the absorption of mycophenolate. Monitor blood concentrations if used together.
• Levothyroxine: Karvela 800 may reduce the effectiveness of levothyroxine. Monitor thyroid-stimulating hormone (TSH) levels.
• Erdafitinib: Interaction with efitinib may occur; consult your doctor.

Drug-Food Interactions:

• High-Phosphate Additives: Avoid high-phosphate additives in your diet as they can interfere with Karvela 800R’s effectiveness.
• Alcohol: Avoid alcohol consumption as it can increase side effects.
• Multivitamins with Minerals: Karvela 800 may decrease the effectiveness of multivitamins with minerals. Take multivitamins at least 4 hours before or after taking Karvela 800.

Drug-Disease Interactions:

• Hypophosphatemia: Karvela 800 is contraindicated in patients with low phosphate levels.
• Bowel Obstruction and Perforation: Karvela 800 should not be used in cases of bowel obstruction or perforation.
• Severe Liver Disease: Use Karvela 800 with caution in patients with severe liver disease.

✔️ Contraindications

Do not use Sevelamer if you are allergic to it.

✔️ Pregnancy & Lactation

• Pregnancy: Not systemically absorbed; however, it may decrease serum levels of fat-soluble vitamins and folic acid.
• Lactation: Not expected to be absorbed by the child; may also decrease serum levels of fat-soluble vitamins and folic acid.

✔️ Precautions & Warnings

• Consult your doctor if you have swallowing disorders, have had recent digestive tract surgery, severe constipation, or major surgery on your stomach or bowel, or have serious inflammatory bowel disease.
• Use Sevelamer with caution if you are pregnant or planning to become pregnant. It is not recommended for breastfeeding mothers, as it may pass into breast milk.
• Avoid alcohol while taking Sevelamer as it may cause unpleasant side effects.
• Sevelamer should not be given to children under six years of age, as its safety and effectiveness in this age group have not been established.
• Sevelamer contains lactose. If you have lactose intolerance, consult your doctor before taking this medication.
• Regular monitoring of serum phosphate levels, and levels of vitamins D, A, E, K, and folic acid is advised while taking Sevelamer.

✔️ Storage Conditions:

Store in a cool, dry place, protected from light.