Karvela 800mg 4pcs Tablet

Uses of Karvela 800

Treats Hyperphosphatemia (high phosphorus level in blood)

Side Effects of Karvela 800

Abdominal pain, Diarrhea, Flatulence, Vomiting, Constipation, Nausea, Dyspepsia

How does Karvela 800 work?

Karvela 800 is a chelating agent that helps reduce the phosphorus levels in the blood by binding to the phosphate that enters the body with food and managing its absorption.

Quick Suggestions:

• Sevelamer is used to control blood phosphate levels in patients who are on dialysis treatment.
• You must take it with food and stick to the diet prescribed by your doctor.
• You may develop low levels of calcium, folic acid, and vitamins A, D, E, and K in your blood. Your doctor may prescribe supplements, if necessary.
• Avoid taking any other medicine 1 hour before or 3 hours after taking Sevelamer.
• Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.

Indication of Karvela 800

• Control of hyperphosphatemia in adults receiving hemodialysis or peritoneal dialysis.
• Control of hyperphosphatemia in adults with chronic kidney disease (CKD) not on dialysis, with serum phosphorus ≥1.78 mmol/L.
• Should be part of a comprehensive treatment approach, potentially including calcium supplements and vitamin D3 or analogs to manage the renal bone disease.

Pharmacology

Sevelamer carbonate is a non-absorbed phosphate-binding polymer free of metals and calcium. It binds phosphate in the gastrointestinal tract through ionic and hydrogen bonding, reducing phosphate absorption and lowering serum phosphorus levels.

Dosage & Administration of Karvela 800

For End-Stage Renal Disease (ESRD) Hemodialysis and Hyperphosphatemia:

Initial Dose:

• Serum PO4 >9 mg/dL [2.91 mmol/L]: 1600 mg orally every 8 hours with meals.
• Serum PO4 7.5-9 mg/dL [2.42-2.91 mmol/L]: 1200-1600 mg orally every 8 hours with meals.
• Serum PO4 5.5-7.5 mg/dL [1.78-2.42 mmol/L]: 800 mg orally every 8 hours with meals.

Maintenance Dose:

• Serum PO4 >5.5 mg/dL [>1.78 mmol/L]: Increase dose by 400-800 mg per meal.
• Serum PO4 3.5-5.5 mg/dL [1.13-1.78 mmol/L]: Maintain current dose.
• Serum PO4 <3.5 mg/dL [1.13 mmol/L]: Decrease dose by 400-800 mg per meal.

Dosing Considerations:

• Titrate the dose by increasing it by 400-800 mg per meal at 2-week intervals.
• Do not exceed a total daily dose of 4 grams.

Switching from Calcium Acetate:

• Substitute 800 mg of SEVELAMER for 667 mg of calcium acetate.
• Substitute 1600 mg of SEVELAMER for 1334 mg of calcium acetate.
• Substitute 2400 mg of SEVELAMER for 2001 mg of calcium acetate.

Pediatric Dose:

• The safety and efficacy of Karvela 800 in children have not been established. It is not recommended for use in pediatric patients.

Interaction

Drug-Drug Interactions:

• Ciprofloxacin: Karvela 800 may decrease the absorption of ciprofloxacin. It should not be taken simultaneously with this antibiotic.
• Mycophenolate: Karvela 800 may affect the absorption of mycophenolate. Monitor blood concentrations if used together.
• Levothyroxine: Karvela 800 may reduce the effectiveness of levothyroxine. Monitor thyroid-stimulating hormone (TSH) levels.
• Erdafitinib: Interaction with efitinib may occur; consult your doctor.

Drug-Food Interactions:

• High-Phosphate Additives: Avoid high-phosphate additives in your diet as they can interfere with Karvela 800R’s effectiveness.
• Alcohol: Avoid alcohol consumption as it can increase side effects.
• Multivitamins with Minerals: Karvela 800 may decrease the effectiveness of multivitamins with minerals. Take multivitamins at least 4 hours before or after taking Karvela 800.

Drug-Disease Interactions:

• Hypophosphatemia: Karvela 800 is contraindicated in patients with low phosphate levels.
• Bowel Obstruction and Perforation: Karvela 800 should not be used in cases of bowel obstruction or perforation.
• Severe Liver Disease: Use Karvela 800 with caution in patients with severe liver disease.

Contraindications

Do not use Sevelamer if you are allergic to it.

Pregnancy & Lactation

• Pregnancy: Not systemically absorbed; however, it may decrease serum levels of fat-soluble vitamins and folic acid.
• Lactation: Not expected to be absorbed by the child; may also decrease serum levels of fat-soluble vitamins and folic acid.

Precautions & Warnings

• Consult your doctor if you have swallowing disorders, have had recent digestive tract surgery, severe constipation, or major surgery on your stomach or bowel, or have serious inflammatory bowel disease.
• Use Sevelamer with caution if you are pregnant or planning to become pregnant. It is not recommended for breastfeeding mothers, as it may pass into breast milk.
• Avoid alcohol while taking Sevelamer as it may cause unpleasant side effects.
• Sevelamer should not be given to children under six years of age, as its safety and effectiveness in this age group have not been established.
• Sevelamer contains lactose. If you have lactose intolerance, consult your doctor before taking this medication.
• Regular monitoring of serum phosphate levels, and levels of vitamins D, A, E, K, and folic acid is advised while taking Sevelamer.

Storage Conditions:

Store in a cool, dry place, protected from light.